Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and levetiracetam
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8jlc
Q-score: 0.454
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- (2s)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide (170 Da, Ligand)
- Sv2a in complex with bont/a2 hc domain and anti-epileptic drug, levetiracetam (Complex from Homo sapiens)
- Synaptic vesicle glycoprotein 2a (83 kDa, Protein from Homo sapiens)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8jle
Q-score: 0.517
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- Synaptic vesicle glycoprotein 2a (12 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- Sv2a in complex with bont/a2 hc domain and anti-epileptic drug, levetiracetam (Complex from Homo sapiens)
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8jlf
Q-score: 0.48
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- Synaptic vesicle glycoprotein 2a (83 kDa, Protein from Homo sapiens)
- Sv2a in complex with bont/a2 hc domain (Complex from Homo sapiens)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8jlg
Q-score: 0.551
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- Sv2a ld4 in complex with bont/a2 hc domain from the sv2a-bont/a2 hc complex (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- Synaptic vesicle glycoprotein 2a (13 kDa, Protein from Homo sapiens)
Cryo-EM structure of SV2A dimer in complex with BoNT/A2 Hc and levetiracetam
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jlh
Q-score: 0.49
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- (2s)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide (170 Da, Ligand)
- Sv2a dimer in complex with bont/a2 hc domain and anti-epileptic drug, levetiracetam (Complex from Homo sapiens)
- Synaptic vesicle glycoprotein 2a (83 kDa, Protein from Homo sapiens)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SV2A dimer in complex levetiracetam
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8jli
Q-score: 0.351
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and levetiracetam
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8js8
Q-score: 0.54
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- (2s)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide (170 Da, Ligand)
- Sv2a in complex with bont/a2 hc domain and anti-epileptic drug, levetiracetam (Complex from Homo sapiens)
- Synaptic vesicle glycoprotein 2a (83 kDa, Protein from Homo sapiens)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8js9
Q-score: 0.54
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- Synaptic vesicle glycoprotein 2a (83 kDa, Protein from Homo sapiens)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- Sv2a in complex with bont/a2 hc (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and brivaracetam
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 8k77
Q-score: 0.477
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ Pubmed: 38637505 DOI: doi:10.1038/s41467-024-47322-4 ]
- Synaptic vesicle glycroprotein 2a in complex with brivaracetam and botulinum neurotoxin a2 hc domain (Complex from Homo sapiens)
- Synaptic vesicle glycoprotein 2a (83 kDa, Protein from Homo sapiens)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- (2s)-2-[(4r)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide (212 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)